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Steve Miller, MD, PhD

Research and Clinical Interests

I am interested in the use of molecular methods for diagnosis and monitoring of clinical infectious disease, particularly in immunocompromised and transplant patients. Conventional clinical testing often is unable to identify pathogens of interest in patient samples, and my research aims to develop methods to better identify infectious agents, which could improve patient care and public health. Projects include:

  1. Clinical evaluation and implementation of quantitative PCR measurements of viral illness (EBV, BK, JC, CMV) and multiplex identification of these agents in disease or symptom-specific panels.
  2. Development and evaluation of microarray and deep sequencing assays for microbial identification of viral, bacterial, fungal and parasitic pathogens for diagnosis of clinical infection.
  3. 3. Viral and bacterial identification, strain typing, and prediction of phenotypic resistance profiles using microarrays and deep sequencing genomic methods.

Selected Publications

  • Miller S, Seet H, Khan Y, Wright C and Nadarajah R. Comparison of QIAGEN Automated Nucleic Acid Extraction Methods for CMV Quantitative PCR Testing. American Journal of Clinical Pathology 2010;133:558-63.
  • Miller SA, van Zante A and Schwartz BS. Cytologic evaluation can predict microbial culture results for infectious causes of pulmonary nodules in patients undergoing fine needle aspiration biopsy. Diagnostic Microbiology and Infectious Disease 2010;68:330-3.
  • Greninger AL, Chen EC, Sittler T, Schneierman A, Roubinian N, Yu G, Kim E, Pillai D, Guyard C, Mazzulli T, Isa P, Arias CF, Hackett J, Schochetman G, Miller S, Tang P and Chiu CY. A Metagenomic Analysis of Pandemic Influenza A (2009 H1N1) Infection in Patients from North America. PLoS One 2010;5:e13381.
  • Wiita A, Roubinian N, Khan Y, Chin-Hong P, Singer J, Golden J and Miller S. Cytomegalovirus Disease and Infection in Lung Transplant Recipients in the Setting of Planned Indefinite Valganciclovir Prophylaxis. Transplant Infectious Disease 2012;14:248-58.
  • Miller S, Liverman CS, Post L, Khan Y and Wright C. Analytical and clinical performance characteristics of the Simplexa BK virus quantitative PCR assay for the diagnosis of polyomavirus-associated nephropathy in renal transplant recipients using plasma and urine specimens. Journal of Clinical Virology 2012;55:310-6.

Selected Awards

  • 2006: Paul E. Strandjord Young Investigator Award
  • 2006-2007: College of American Pathologists Foundation Scholar
Steve Miller, MD, PhD
  • Associate Professor and Director, UCSF Clinical Microbiology Laboratory
  • Laboratory Medicine
  • Infectious Disease/Microbial Pathogenesis

Specialty Area

  • Molecular Microbiology

Contact Information

  • 185 Berry Street, Suite 290
  • Box 0100
  • San Francisco, CA 94107

Hospital Affiliation(s)

  • UCSF Medical Center
  • UCSF Childrens Hospital
  • Mt. Zion Medical Center
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