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Research and Clinical Interests

The long-term goal of our basic research is to elucidate how neuronal signaling and synaptic plasticity contribute to the selective vulnerability of different neuronal populations and thus influence onset and/or progression of different neurologic disorders. To accomplish this goal, we are investigating two distinct but related areas: (1) the role of intrinsic antioxidant defenses in the regulation of neuronal survival and in the modulation of neuronal signaling, and (2) the role of microRNAs in synaptic plasticity and malplasticity. The goal of our translational research is to improve tissue-based diagnostics of neurologic disorders; our current focus is on tools for pathologic diagnosis of neuromuscular diseases.

Selected Publications

• Margeta M., Connolly A.M., Widner T.L., Pestronk A., and Moore S.A.: Cardiac pathology exceeds skeletal muscle pathology in two cases of limb-girdle muscular dystrophy type 2I. Muscle Nerve; in press. (2009)
• Layzer R., Lee H., Iverson D., and Margeta M.: Dermatomyositis with inclusion body myositis pathology. Muscle Nerve; in press. (2009)
• Keet, C.A., Fox, C.K., Margeta, M., Marco, E., Shane, A.L., DeArmond, S.J., Strober, J.B., and Miller, S.P.: Infant botulism, type F, presenting at 54 hours of life. Pediatr Neurol, 32:193-196 (2005)
• Margeta-Mitrovic, M., Jan, Y. N. and Jan, L. Y.: Function of GB1 and GB2 subunits in G protein coupling of GABA_B receptors. Proc. Natl. Acad. Sci. U.S.A. 98:14649-14654 (2001)
• Margeta-Mitrovic, M., Jan, Y. N. and Jan, L. Y.: A trafficking checkpoint controls GABA_B receptor heterodimerization. Neuron 27:97-106 (2000)

Selected Awards

• 2007- NIH Mentored Clinical Scientist Development Award
• 1997-2000 NIH Institutional Research Service Award
• 1996 Klaus R. Unna Award, for outstanding research accomplishments as a graduate student
• 1996 AFAR/Glenn Foundation Scholarship for Research in the Biology of Aging
• 1993-1994 University of Illinois Graduate College Fellowship
• 1990 University of Zagreb Chancellor’s Award, for outstanding academic performance as a medical student

• Assistant Professor
• Pathology
• Neuropathology

Specialty Area

Neuroscience Research; Neuromuscular Pathology and Autopsy Neuropathology

Contact Information

• Marta.Margeta@ucsf.edu
• Phone: 415-514-0228
• Fax: 415-514-3165

• UCSF Department of Pathology
• 513 Parnassus Avenue
• Room HSW-514, Box 0511
• San Francisco CA 94143-0511

Web Sites

• Margeta Lab Website
• Biomedical Sciences (BMS) Graduate Program

Other UCSF Organizational Association(s)

• Biomedical Sciences (BMS) Graduate Program

Hospital Affiliation(s)

• Moffitt-Long